Structure of PDB 8uvo Chain B

Receptor sequence

>8uvoB (length=549) Species: 9606 (Homo sapiens) [Search protein sequence]

EVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGT
GKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPA
IIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNR
PNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQV
ANETHGHVGADLAALCSEAALQAIRKKMDIDAEVMNSLAVTMDDFRWALS
QSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFG
MTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEA
NVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTE
MDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAIL
KANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEI
RRERERQTNPSDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ

3D structure

PDB

8uvo Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors.

Chain

Resolution

3.22 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ADP	B	D205 G207 G248 T249 G250 K251 T252 L253 I380 H384 G408 A409	D6 G8 G49 T50 G51 K52 T53 L54 I181 H185 G209 A210
BS02	ADP	B	I479 G480 G521 C522 G523 K524 T525 I656	I272 G273 G314 C315 G316 K317 T318 I449
BS03	XNU	B	V493 V497 L504 P510 S511 K512 C535 C572 K615 N616 F618	V286 V290 L297 P303 S304 K305 C328 C365 K408 N409 F411

External links

PDB	RCSB:8uvo, PDBe:8uvo, PDBj:8uvo
PDBsum	8uvo
PubMed	39122922
UniProt	P55072\|TERA_HUMAN Transitional endoplasmic reticulum ATPase (Gene Name=VCP)

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