Structure of PDB 8uv1 Chain B

Receptor sequence
>8uv1B (length=436) Species: 9606 (Homo sapiens) [Search protein sequence]
NPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWL
VKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGT
HHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHK
SGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGR
FQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKW
LCSEFKESMLTLGKESSSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQT
AEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSAN
LSKAAWGALEKNGTQLMIRSYELGVLFLPSAFGLDSFKVKQKFFAGATFP
VPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVP
3D structure
PDB8uv1 Structure of TDP1 complexed with compound IB01
ChainB
Resolution1.83 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XK6 B P163 F164 F553 K554 A568 T569 P2 F3 F387 K388 A397 T398
BS02 XK6 B H263 S400 P461 N516 H102 S239 P295 N350
BS03 XK6 B G308 H310 G147 H149
BS04 XK6 B Y204 H263 S399 S459 P461 H493 K495 N516 Y43 H102 S238 S293 P295 H327 K329 N350
BS05 XK6 B G173 V174 P176 G12 V13 P15
External links
PDB RCSB:8uv1, PDBe:8uv1, PDBj:8uv1
PDBsum8uv1
PubMed
UniProtQ9NUW8|TYDP1_HUMAN Tyrosyl-DNA phosphodiesterase 1 (Gene Name=TDP1)

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