Structure of PDB 8utt Chain B

Receptor sequence

>8uttB (length=432) Species: 9823 (Sus scrofa)

MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVY
YNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNN
WAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTL
LISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETY
CIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADL
RKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVK
TAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTG
EGMDEMEFTEAESNMNDLVSEYQQYQDATADE

3D structure

• PDB: 8utt Cryo-EM of human KIF1A reveals its mechanism of motility and the effect of its pathogenic variant P305L
• Chain: B
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GDP	B	G10 Q11 C12 Q15 S138 G142 T143 G144 N204 Y222	G10 Q11 C12 Q15 S138 G142 T143 G144 N204 Y222
BS02	TA1	B	E22 V23 D26 E27 L215 D224 H227 L228 F270 P272 L273 T274 R276 P358 R359 G360 L361	E22 V23 D26 E27 L215 D224 H227 L228 F270 P272 L273 T274 R276 P358 R359 G360 L361

Gene Ontology

Molecular Function

• GO:0005525 GTP binding

Biological Process

• GO:0007010 cytoskeleton organization

Cellular Component

• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0005874 microtubule

External links

• PDB: RCSB:8utt, PDBe:8utt, PDBj:8utt
• PDBsum: 8utt
• PubMed: 38956021
• UniProt: A0A287AGU7