Structure of PDB 8un0 Chain B

Receptor sequence
>8un0B (length=319) Species: 9606 (Homo sapiens) [Search protein sequence]
HYELPWVEKYRPVKLNEIVGNEDTVSRLEVFAREGNVPNIIIAGPPGTGK
TTSILCLARALLGPALKDAMLELNASNDRGIDVVRNKIKMFAQQKVTLPK
GRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQ
SRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQA
LNNLQSTFSGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKIL
AHLWHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVN
SLLQMAGLLARLCQKTMAP
3D structure
PDB8un0 Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC.
ChainB
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B G112 I113 G80 I81
BS02 dna B D175 K304 D143 K272
BS03 AGS B R155 R184 R123 R152
BS04 AGS B V39 R43 P44 I50 V51 P78 G79 T80 G81 K82 T83 T84 N172 M229 R230 V7 R11 P12 I18 V19 P46 G47 T48 G49 K50 T51 T52 N140 M197 R198
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0019899 enzyme binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair
GO:0032508 DNA duplex unwinding
GO:1900264 positive regulation of DNA-directed DNA polymerase activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005663 DNA replication factor C complex
GO:0031390 Ctf18 RFC-like complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8un0, PDBe:8un0, PDBj:8un0
PDBsum8un0
PubMed38669181
UniProtP35250|RFC2_HUMAN Replication factor C subunit 2 (Gene Name=RFC2)

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