Structure of PDB 8uh6 Chain B

Receptor sequence
>8uh6B (length=386) Species: 9606 (Homo sapiens) [Search protein sequence]
PNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIP
GQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYA
YREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPST
MSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRW
LYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDV
LRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLC
GPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKI
CASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDT
3D structure
PDB8uh6 Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex.
ChainB
Resolution3.3 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WO8 B N351 P352 W380 W386 W400 F402 N308 P309 W337 W343 W357 F359
BS02 ZN B C323 C394 C280 C351
External links
PDB RCSB:8uh6, PDBe:8uh6, PDBj:8uh6
PDBsum8uh6
PubMed39152201
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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