Structure of PDB 8ufu Chain B

Receptor sequence
>8ufuB (length=401) Species: 9606 (Homo sapiens) [Search protein sequence]
FPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPAPEQLLSQARD
FINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWR
NAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAIT
VFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGW
TPGNGRFDVLPLLLQAPDEPPELFLLPPELVLEVPLEHPTLEWFAALGLR
WYALPAVSNMLLEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDV
AVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMK
HLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDP
W
3D structure
PDB8ufu Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase.
ChainB
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.13.39: nitric-oxide synthase (NADPH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WRI B W74 W445 F460 W7 W366 F381
BS02 ZN B C94 C99 C27 C32
BS03 HEM B W178 R183 C184 F353 W356 E361 R365 F473 Y475 W99 R104 C105 F274 W277 E282 R286 F394 Y396
BS04 WRI B V336 F353 W356 E361 W447 V257 F274 W277 E282 W368
BS05 WRI B V104 H371 A446 W447 V37 H292 A367 W368
Gene Ontology
Molecular Function
GO:0004517 nitric-oxide synthase activity
Biological Process
GO:0006809 nitric oxide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ufu, PDBe:8ufu, PDBj:8ufu
PDBsum8ufu
PubMed38417024
UniProtP29474|NOS3_HUMAN Nitric oxide synthase 3 (Gene Name=NOS3)

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