Structure of PDB 8udu Chain B

Receptor sequence
>8uduB (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
LPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIVTVAVKMLKDDATD
KDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREF
LRARRSGEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTED
NVMKIADFGLARDVHNLDYYKKTTGRLPVKWMAPEALFDRVYTHQSDVWS
FGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRE
CWHAAPSQRPTFKQLVEDLDRVLTVT
3D structure
PDB8udu Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations.
ChainB
Resolution1.737 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WIQ B L478 C482 F483 A506 K508 E525 M529 V553 V555 Y557 A558 L624 D635 L20 C24 F25 A40 K42 E59 M63 V87 V89 Y91 A92 L146 D157
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8udu, PDBe:8udu, PDBj:8udu
PDBsum8udu
PubMed38267212
UniProtP22607|FGFR3_HUMAN Fibroblast growth factor receptor 3 (Gene Name=FGFR3)

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