Structure of PDB 8udt Chain B

Receptor sequence
>8udtB (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
LELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVA
VKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVE
YAAKGNLREFLRARRSGEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDL
AARNVLVTEDNVMKIADFGLARDVHNLDYYKKTRLPVKWMAPEALFDRVY
THQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTH
DLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTV
3D structure
PDB8udt Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations.
ChainB
Resolution2.829 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WGF B L478 G481 C482 Q485 V486 K508 L522 E525 V553 V555 A558 L624 L22 G25 C26 Q29 V30 K52 L66 E69 V97 V99 A102 L156
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8udt, PDBe:8udt, PDBj:8udt
PDBsum8udt
PubMed38267212
UniProtP22607|FGFR3_HUMAN Fibroblast growth factor receptor 3 (Gene Name=FGFR3)

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