Structure of PDB 8ucd Chain B

Receptor sequence
>8ucdB (length=237) Species: 9606 (Homo sapiens) [Search protein sequence]
LFPQWHLPIKIAAIIASLTFLYTLLREVIHPLATSHQQYFYKIPILVINK
VLPMVSITLLALVYLPGVIAAIVQLFPHWLDKWMLTRKQFGLLSFFFAVL
HAIYSLSYPMRRSYRYKLLNWAYQQVQQNKEDAWIEHDVWRMEIYVSLGI
VGLAILALLAVTSIPSVSDSLTWREFHYIQSKLGIVSLLLGTIHALIFAW
NKWIDIKQFVWYTPPTFMIAVFLPIVVLIFKSILFLP
3D structure
PDB8ucd AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity Against Prostate Cancer.
ChainB
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LBN B Q70 W71 F169 F170 I177 V235 P239 Q4 W5 F95 F96 I103 V161 P165
BS02 FAD B R161 K162 G165 L233 H251 Q254 R87 K88 G91 L159 H177 Q180
BS03 HEM B K116 P119 H175 G223 I224 L227 H268 F291 K50 P53 H101 G149 I150 L153 H194 F217
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0052851 ferric-chelate reductase (NADPH) activity
Cellular Component
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0010008 endosome membrane
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:8ucd, PDBe:8ucd, PDBj:8ucd
PDBsum8ucd
PubMed37861452
UniProtQ9UHE8|STEA1_HUMAN STEAP1 protein (Gene Name=STEAP1)

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