Structure of PDB 8u7w Chain B

Receptor sequence
>8u7wB (length=498) Species: 9606 (Homo sapiens) [Search protein sequence]
TSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAV
THIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEGDVIELKYPLN
CADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRT
GDDDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGT
VLQLKQPLNTTRINAAEIESRVRELSKQGFWEEFETLQQQECKLLYSRKE
GQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEKKSY
IATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYAL
KEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHG
VPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILID
IIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL
3D structure
PDB8u7w Discovery of 5-Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors.
ChainB
Resolution2.05 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 W8I B R111 F113 T218 T219 E250 T253 L254 D489 P491 K492 R108 F110 T210 T211 E233 T236 L237 D462 P464 K465
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8u7w, PDBe:8u7w, PDBj:8u7w
PDBsum8u7w
PubMed38116446
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

[Back to BioLiP]