Structure of PDB 8u1f Chain B

Receptor sequence
>8u1fB (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
PKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKD
DATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN
LREYLRARRPPVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN
VLVTENNVMKIADFGLALPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIF
TLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR
PTFKQLVEDLDRILTLTT
3D structure
PDB8u1f Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2.
ChainB
Resolution3.33 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UIM B L487 C491 F492 A515 M538 I548 Y566 A567 R630 N631 L633 A643 F645 L16 C20 F21 A44 M67 I77 Y95 A96 R149 N150 L152 A162 F164
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:8u1f, PDBe:8u1f, PDBj:8u1f
PDBsum8u1f
PubMed38300868
UniProtP21802|FGFR2_HUMAN Fibroblast growth factor receptor 2 (Gene Name=FGFR2)

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