Structure of PDB 8tx0 Chain B

Receptor sequence

>8tx0B (length=292) Species: 9606 (Homo sapiens) [Search protein sequence]

RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVK
KLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYV
YMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIK
SANILLDEAFTAKISDFGLARASETVMTSRIVGTTAYMAPEALRGEITPK
SDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKK
MNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA

3D structure

PDB

8tx0 Discovery of BIO-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation.

Chain

Resolution

2.0 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	VEU	B	M192 A211 Y262 V263 Y264 M265 P266 G268 L318 D329	M29 A48 Y99 V100 Y101 M102 P103 G105 L155 D166

External links

PDB	RCSB:8tx0, PDBe:8tx0, PDBj:8tx0
PDBsum	8tx0
PubMed	38695469
UniProt	Q9NWZ3\|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

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