Structure of PDB 8tvx Chain B

Receptor sequence
>8tvxB (length=1041) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
DESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDYTLQDIICEDSTL
ILEKYEISFGKIYVTKPMVNESDGVTHALYPQEARLRNLTYSSGLFVDVK
KRTYEASGKVFIGRLPIMLRSKNCYLSEATESDLYKLKECPFDMGGYFII
NGSEKVLIAQERSAGNIVQVFKKAAPSPISHVAEIRSASTLQVKLYGREG
SSARTIKATLPYIKQDIPIVIIFRALGIIPDGEILEHICYDVNDWQMLEM
LKPCVEDGFVIQDRETALDFIGRRGTKRIQYAKDILQKEFLPHITQLEGF
ESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTL
FKKLTKDIFRYMQRTFNMKLAINAKTITSGLKYALATGNWGRAGVSQVLN
RYTYSSTLSHLRRTNTPILHNTHWGLVCPAETPEGQACGLVKNLSLMSCI
SVGTDPMPIITFLSEWGMEPLEDYVPHQSPDATRVFVNGVWHGVHRNPAR
LMETLRTLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVEDDES
LGHKELKVRKGHIAKLMATEYQDIEGGEEYTWSSLLNEGLVEYIDAEEEE
SILIAMQPEDLEPAEANTTFTHCEIHPSMILGVAASIIPFPDHNQSPRNT
YQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELP
AGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGM
SITETFEKPQRENGIVDQVLVTTNQDGLKFVKVRVRTTKIPQIGDKFASR
HGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSK
VAALSGNEGDASPFTDITVEGISKLLREHGYQSRGFEVMYNGHTGKKLMA
QIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEM
ERDCMIAHGAASFLKERLMEASDAFRVHICGICGLMTVIAKLNHNQFECK
GCDNKIDIYQIHIPYAAKLLFQELMAMNITPRLYTDRSRDF
3D structure
PDB8tvx Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair.
ChainB
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B K210 G1121 R1122 S1123 R1129 K155 G938 R939 S940 R946
BS02 rna B Q776 K987 R1124 Q658 K804 R941
BS03 ZN B C1163 C1166 C1182 C1185 C980 C983 C999 C1002
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003729 mRNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0006368 transcription elongation by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0005739 mitochondrion
GO:0010494 cytoplasmic stress granule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tvx, PDBe:8tvx, PDBj:8tvx
PDBsum8tvx
PubMed38194460
UniProtP08518|RPB2_YEAST DNA-directed RNA polymerase II subunit RPB2 (Gene Name=RPB2)

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