Structure of PDB 8tvm Chain B

Receptor sequence
>8tvmB (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVK
KLAADITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYM
PNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSA
NILLDEAFTAKISDFGLARASTVMTSRIVGTTAYMAPEALRGEITPKSDI
YSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA
3D structure
PDB8tvm A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 Inhibitors.
ChainB
Resolution2.1 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VDC B M192 V200 A211 K213 Y262 V263 Y264 M265 P266 G268 L318 M29 V37 A48 K50 Y97 V98 Y99 M100 P101 G103 L153
External links
PDB RCSB:8tvm, PDBe:8tvm, PDBj:8tvm
PDBsum8tvm
PubMed38746903
UniProtQ9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

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