Structure of PDB 8tu9 Chain B

Receptor sequence
>8tu9B (length=533) Species: 6100,9606 [Search protein sequence]
LKMDQALLLIHNELLWTNLTVYWKSECCYHCLFQVLVNVPQSPKAGKPSA
AAASVSTQHGSILQLNDTLEEKEVCRLEYRFGEFGNYSLLVKNIHNGVSE
IACDLAVNEDPVDSNLPVSIAFLIGLAVIIVISFPPRLRSVDTFRGIALI
LMVFVNYGGGKYWYFKHASWNGLTVADLVFPWFVFIMGSSIFLSMTSILQ
RGCSKFRLLGKIAWRSFLLICIGIIIVNPNYCLGPLSWDKVRIPGVLQRL
GVTYFVVAVLELLFAKPVPEHCASERSCLSLRDITSSWPQWLLILVLEGL
WLGLTFLLPVPGCPTGYLGPGGIGDFGKYPNCTGGAAGYIDRLLLGDDHL
YQHPSSAVLYHTEVAYDPEGILGTINSIVMAFLGVQAGKILLYYKARTKD
ILIRFTAWCCILGLISVALTKVSENEGFIPVNKNLWSLSYVTTLSSFAFF
ILLVLYPVVDVKGLWTGTPFFYPGMNSILVYVGHEVFENYFPFQWKLKDN
QSHKEHLTQNIVATALWVLIAYILYRKKIFWKI
3D structure
PDB8tu9 Structure of the human heparan-alpha-glucosaminide N-acetyltransferase (HGSNAT)
ChainB
Resolution3.26 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.78: heparan-alpha-glucosaminide N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACO B R239 R247 M254 F282 S292 L295 S296 L352 Y583 K634 R137 R145 M152 F180 S190 L193 S194 L250 Y481 K532
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0015019 heparan-alpha-glucosaminide N-acetyltransferase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0007041 lysosomal transport
GO:0008218 bioluminescence
GO:0030200 heparan sulfate proteoglycan catabolic process
GO:0051259 protein complex oligomerization
Cellular Component
GO:0005575 cellular_component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0035579 specific granule membrane
GO:0043202 lysosomal lumen
GO:0070821 tertiary granule membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tu9, PDBe:8tu9, PDBj:8tu9
PDBsum8tu9
PubMed39196614
UniProtP42212|GFP_AEQVI Green fluorescent protein (Gene Name=GFP);
Q68CP4|HGNAT_HUMAN Heparan-alpha-glucosaminide N-acetyltransferase (Gene Name=HGSNAT)

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