Structure of PDB 8to4 Chain B

Receptor sequence
>8to4B (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
ALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREKA
NKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREH
KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITD
FGLALLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIP
ASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFS
KMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEVDAD
3D structure
PDB8to4 EGFR(T790M/V948R) in complex with the allosteric inhibitor FRF-06-057
ChainB
Resolution2.99 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B N842 D855 N137 D150
BS02 ANP B G719 S720 G721 V726 A743 K745 Q791 L792 M793 C797 D837 R841 L844 G18 S19 G20 V25 A42 K44 Q86 L87 M88 C92 D132 R136 L139
External links
PDB RCSB:8to4, PDBe:8to4, PDBj:8to4
PDBsum8to4
PubMed
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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