Structure of PDB 8to3 Chain B

Receptor sequence

>8to3B (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]

ALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREAN
KEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHK
DNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDF
GLAKLLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIP
ASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFS
KMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDAD

3D structure

PDB

8to3 EGFR(T790M/V948R) in complex with LN5461

Chain

Resolution

2.49 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	B	N842 D855	N136 D149
BS02	ANP	B	G719 A722 V726 A743 K745 L792 M793 R841 N842 L844	G18 A21 V25 A42 K44 L86 M87 R135 N136 L138

External links

PDB	RCSB:8to3, PDBe:8to3, PDBj:8to3
PDBsum	8to3
PubMed
UniProt	P00533\|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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