Structure of PDB 8tny Chain B

Receptor sequence
>8tnyB (length=545) Species: 9606 (Homo sapiens) [Search protein sequence]
HRILIERQEMSGLIVGILLVPQSIAYSLLAGQEPVYGLYTSFFASIIYFL
LGTSRHISVGIFGVLCLMIGETVDRELQKAGYICDKSCYAIMVGSTVTFI
AGVYQVAMGFFQVGFVSVYLSDALLSGFVTGASFTILTSQAKYLLGLNLP
RTNGVGSLITTWIHVFRNIHKTNLCDLITSLLCLLVLLPIELVVVVAATL
ASHFGKLHENYNSSIAGHIPTGFMPPKVPEWNLIPSVAVDAIAISIIGFA
ITVSLSEMFAKKHGYTVKANQEMYAIGFCNIIPSFFHCFTTSAALAKTLV
KEQLSGVVTALVLLLVLLVIAPLFYSLQKSVLGVITIVNLRGALRKFRDL
PKMWSISRMDTVIWFVTMLSSALLSTEIGLLVGVCFSIFCVILRTQKPKS
SLLGLVEESEVFESVSAYKNLQIKPGIKIFRFVAPLYYINKECFKSALYK
QTVNPILIKVAWKKAELHTIVIDCSAIQFLDTAGIHTLKEVRRDYEAIGI
QVLLAQCNPTVRDSLTNGEYCKKEEENLLFYSVYEAMAFAEVSKN
3D structure
PDB8tny Substrate binding plasticity revealed by Cryo-EM structures of SLC26A2.
ChainB
Resolution3.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 B Y129 F165 A441 Y26 F62 A296
Gene Ontology
Molecular Function
GO:0005452 solute:inorganic anion antiporter activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015116 sulfate transmembrane transporter activity
GO:0019531 oxalate transmembrane transporter activity
Biological Process
GO:0001503 ossification
GO:0002062 chondrocyte differentiation
GO:0015701 bicarbonate transport
GO:0019532 oxalate transport
GO:0035988 chondrocyte proliferation
GO:1902358 sulfate transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0031528 microvillus membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tny, PDBe:8tny, PDBj:8tny
PDBsum8tny
PubMed38684689
UniProtP50443|S26A2_HUMAN Sulfate transporter (Gene Name=SLC26A2)

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