Structure of PDB 8tlq Chain B

Receptor sequence
>8tlqB (length=248) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
TVYTREAYFHEKAHGQTLQDQILKDQYKDQISSQSSKIFKNCVIYINGYT
KPGRLQLHEMIVLHGGKFLHYLSSKKTVTHIVASNLPLKKRIEFANYKVV
SPDWIVDSVKEARLLPWQNYSLTSKNHFMGQNSIFQPIKFQNLTRFKKIC
QLVKQWVAETLGDGGPHEKDVKLFVKYLIKLCDSNRVHLVLHLSNLISRE
LNLCAFLNQDHSGFQTWERILLNDIIPLLNRNKHTYQTVRKLDMDFEV
3D structure
PDB8tlq Cryo-EM structure of the Rev1-Pol zeta holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis.
ChainB
Resolution3.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B K202 K203 K75 K76
BS02 dna B R132 Y135 K217 R5 Y8 K90
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0017125 deoxycytidyl transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0042276 error-prone translesion synthesis
GO:0070987 error-free translesion synthesis
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005657 replication fork
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tlq, PDBe:8tlq, PDBj:8tlq
PDBsum8tlq
PubMed38720088
UniProtP12689|REV1_YEAST DNA repair protein REV1 (Gene Name=REV1)

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