Structure of PDB 8tl6 Chain B

Receptor sequence
>8tl6B (length=353) Species: 9606 (Homo sapiens) [Search protein sequence]
MRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIE
FSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCLAFN
SGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFAS
SSDDGRVLIWDIRESPHGEPFCLANYPSAFHSVMFNPVEPRLLATANSKE
GVGLWDIRKPQSSLLRYGQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSR
LPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPRV
VNGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQPGCTGD
LDG
3D structure
PDB8tl6 Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF.
ChainB
Resolution2.63 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E199 L202 I262 H263 E189 L192 I247 H248
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
GO:0045717 negative regulation of fatty acid biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0080008 Cul4-RING E3 ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tl6, PDBe:8tl6, PDBj:8tl6
PDBsum8tl6
PubMed38538798
UniProtQ96JK2|DCAF5_HUMAN DDB1- and CUL4-associated factor 5 (Gene Name=DCAF5)

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