Structure of PDB 8tgk Chain B

Receptor sequence
>8tgkB (length=382) Species: 9606 (Homo sapiens) [Search protein sequence]
SRQLVLVVVFVALLLDNMLFTVVVPIVPTFLYDMEFTGFLEEEITRVGVL
FASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTL
LFVARTLQGIGSSFSSVAGLGMLASVYTDDHERGRAMGTALGGLALGLLV
GAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILAKGTPLFMLLKDPY
ILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLI
GTNLFGVLANKMGRWLCSLIGMLVVGTSLLCVPLAHNIFGLIGPNAGLGL
AIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIADVAFCMGFAIGPSTGGAI
VKAIGFPWLMVITGVINIVYAPLCYYLRSPPA
3D structure
PDB8tgk Structural insights into vesicular monoamine storage and pharmacological interactions
ChainB
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YHR B N35 T39 L233 L236 L240 V316 F342 Y430 N17 T21 L141 L144 L148 V215 F241 Y329
Gene Ontology
Molecular Function
GO:0005335 serotonin:sodium:chloride symporter activity
GO:0008504 monoamine transmembrane transporter activity
GO:0015311 monoamine:proton antiporter activity
GO:0022857 transmembrane transporter activity
GO:0042910 xenobiotic transmembrane transporter activity
Biological Process
GO:0006836 neurotransmitter transport
GO:0006837 serotonin transport
GO:0015842 aminergic neurotransmitter loading into synaptic vesicle
GO:0015844 monoamine transport
GO:0042908 xenobiotic transport
GO:0051610 serotonin uptake
GO:0051649 establishment of localization in cell
GO:0055085 transmembrane transport
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0030672 synaptic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0043195 terminal bouton
GO:0045202 synapse
GO:0070083 clathrin-sculpted monoamine transport vesicle membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tgk, PDBe:8tgk, PDBj:8tgk
PDBsum8tgk
PubMed38499039
UniProtP54219|VMAT1_HUMAN Chromaffin granule amine transporter (Gene Name=SLC18A1)

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