Structure of PDB 8tgh Chain B

Receptor sequence
>8tghB (length=383) Species: 9606 (Homo sapiens) [Search protein sequence]
ASRQLVLVVVFVALLLDNMLFTVVVPIVPTFLYDMEFQGTGFLEEEITRV
GVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGT
YTLLFVARTLQGIGSSFSSVAGLGMLASVYTDDHERGRAMGTALGGLALG
LLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILKGTPLFMLLKD
PYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSY
LIGTNLFGVLANKMGRWLCSLIGMLVVGTSLLCVPLAHNIFGLIGPNAGL
GLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIADVAFCMGFAIGPSTGG
AIVKAIGFPWLMVITGVINIVYAPLCYYLRSPP
3D structure
PDB8tgh Structural insights into vesicular monoamine storage and pharmacological interactions
ChainB
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YHR B N35 F38 T39 L233 L236 V316 E320 F342 Y430 A433 D434 N18 F21 T22 L144 L147 V217 E221 F243 Y331 A334 D335
Gene Ontology
Molecular Function
GO:0005335 serotonin:sodium:chloride symporter activity
GO:0008504 monoamine transmembrane transporter activity
GO:0015311 monoamine:proton antiporter activity
GO:0022857 transmembrane transporter activity
GO:0042910 xenobiotic transmembrane transporter activity
Biological Process
GO:0006836 neurotransmitter transport
GO:0006837 serotonin transport
GO:0015842 aminergic neurotransmitter loading into synaptic vesicle
GO:0015844 monoamine transport
GO:0042908 xenobiotic transport
GO:0051610 serotonin uptake
GO:0051649 establishment of localization in cell
GO:0055085 transmembrane transport
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0030672 synaptic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0043195 terminal bouton
GO:0045202 synapse
GO:0070083 clathrin-sculpted monoamine transport vesicle membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tgh, PDBe:8tgh, PDBj:8tgh
PDBsum8tgh
PubMed38499039
UniProtP54219|VMAT1_HUMAN Chromaffin granule amine transporter (Gene Name=SLC18A1)

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