Structure of PDB 8tfq Chain B

Receptor sequence

>8tfqB (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]

QVQLQESGPGLVKPSGTLSLTCTVSGGFISSRNWWSWVRQPPGKGLEWIG
EVYHTGITNYNPSLKSRVTISVDKSKNQFSLKLSSVTAADTAVYYCAREV
VGPTTGYFDLWGRGTLVTIVSRRLPPSVFPLAPSGGTAALGCLVKDYFPE
PVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV
NHKPSNTKVDKKVEP

3D structure

PDB

8tfq An Engineered Human-Antibody Fragment with Fentanyl Pan-Specificity That Reverses Carfentanil-Induced Respiratory Depression.

Chain

Resolution

1.8 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	7V7	B	W34 E50 T57 N58 E95 G100B	W34 E51 T58 N59 E99 G106

External links

PDB	RCSB:8tfq, PDBe:8tfq, PDBj:8tfq
PDBsum	8tfq
PubMed	37534714

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