Structure of PDB 8tfo Chain B

Receptor sequence
>8tfoB (length=387) Species: 947166 (Ramazzottius varieornatus) [Search protein sequence]
MSNLRHLRVSAPGKIILHGEHAVVYQKTAVALSLGLRTRLDLTETTDGRI
SIIMDKFLQHTSWSVEELSKIIDKVKIDANNPETELDQELVEDLRMMTYS
TQSVALVGFLYILVKLCKFSGKQRPPSIQISISSDIAISAGLGSSAAFAV
CLSASLLSYLGIIVCDRKNCADVDGKLVPSADQLALINHWAFMVEKIVHG
SASGVDNAVSTYGGSIKYRNNELTRIGSGLKLDVLIVDTHVQRDTKKMLD
IVRHRRKLYPAITNPVLEAIDGISETSSKILQHGDGLPTGEEYEVIADLV
RMNQNLLSTLGVSHPKLDVICETASRFGQAGKLTGAGGGGCAIVVLDPDM
RQFEHLRESIIAEYRRMEFKPHLAELGGPGVLFHPVP
3D structure
PDB8tfo Characterization of novel mevalonate kinases from the tardigrade Ramazzottius varieornatus and the psychrophilic archaeon Methanococcoides burtonii.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.36: mevalonate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MEV B I16 E20 H21 V23 S221 D224 I16 E20 H21 V23 S203 D206
Gene Ontology
Molecular Function
GO:0004496 mevalonate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0046872 metal ion binding
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0008299 isoprenoid biosynthetic process
GO:0016126 sterol biosynthetic process
GO:0016310 phosphorylation
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:8tfo, PDBe:8tfo, PDBj:8tfo
PDBsum8tfo
PubMed38411551
UniProtA0A1D1VW28

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