Structure of PDB 8tf3 Chain B

Receptor sequence

>8tf3B (length=602) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]

DWEQYRDRVNMLQQERIRDSPLLQAAKENDLRLLKILLLNDFQQRGAVGE
TALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNL
NLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR
LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEQSLELV
PNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDS
WGEELSFLELVVSSKKREARQILEQTPVKELVSFKWKKYGRPYFCVLASL
YILYMICFTTCCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQDNIR
LVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTILGGPFHVIIITYASL
VLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTIMIQKM
IFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFE
LFLTIIDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRV
AQERDELWRAQVVATTVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVEN
HH

3D structure

PDB

8tf3 Structural mechanism of TRPV5 inhibition by econazole.

Chain

Resolution

2.94 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CPL	B	I341 I348 Y349	I306 I313 Y314
BS02	ERG	B	F456 V459 M466 T479 I482 Q483 I486	F421 V424 M431 T444 I447 Q448 I451
BS03	ERG	B	M497 P527	M462 P492
BS04	CPL	B	F343 T392 M440 L444	F308 T357 M405 L409
BS05	ECN	B	M466 F472 L475	M431 F437 L440
BS06	CPL	B	C494 W495 A498 V499 L502 Y526 P527 L530	C459 W460 A463 V464 L467 Y491 P492 L495
BS07	ERG	B	F504 I565	F469 I530
BS08	ERG	B	C556 A560 I564	C521 A525 I529
BS09	ECN	B	W495 L496	W460 L461

Gene Ontology

	Molecular Function
GO:0005216	monoatomic ion channel activity
GO:0005261	monoatomic cation channel activity
GO:0005262	calcium channel activity
GO:0005516	calmodulin binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding

	Biological Process
GO:0006811	monoatomic ion transport
GO:0006816	calcium ion transport
GO:0035809	regulation of urine volume
GO:0051289	protein homotetramerization
GO:0055074	calcium ion homeostasis
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0098703	calcium ion import across plasma membrane

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016324	apical plasma membrane

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External links

PDB	RCSB:8tf3, PDBe:8tf3, PDBj:8tf3
PDBsum	8tf3
PubMed	38141613
UniProt	Q9XSM3\|TRPV5_RABIT Transient receptor potential cation channel subfamily V member 5 (Gene Name=Trpv5)

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