Structure of PDB 8te3 Chain B

Receptor sequence
>8te3B (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
GSAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMV
KHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYE
GTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLES
NPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIA
KFSKVRTDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSCLARQR
LLGRSWSVPVIRHLFAPLKEYFACV
3D structure
PDB8te3 Crystal structure of the homo-tetrameric DNMT3A methyltransferase domain(R882C/R676K)
ChainB
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B F640 D641 G642 T645 E664 V665 D686 V687 G707 R891 S892 W893 F15 D16 G17 T20 E39 V40 D61 V62 G82 R254 S255 W256
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:8te3, PDBe:8te3, PDBj:8te3
PDBsum8te3
PubMed38600075
UniProtQ9Y6K1|DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (Gene Name=DNMT3A)

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