Structure of PDB 8tdw Chain B

Receptor sequence
>8tdwB (length=471) Species: 9606 (Homo sapiens) [Search protein sequence]
MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNR
FEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFS
HMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED
ICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWD
YFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFH
TRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAID
DMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTG
QIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYNPIDHVS
FYCKTAPNRAIRITKEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKP
QDGDVIAPLITPQKKEWNDST
3D structure
PDB8tdw Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1.
ChainB
Resolution3.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B V156 R372 H376 V378 R451 V42 R258 H262 V264 R337
BS02 rna B V117 I118 N119 H125 D137 R145 V3 I4 N5 H11 D23 R31
BS03 FE B H167 H206 D207 H53 H92 D93
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0004540 RNA nuclease activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008270 zinc ion binding
GO:0008832 dGTPase activity
GO:0016787 hydrolase activity
GO:0016793 triphosphoric monoester hydrolase activity
GO:0032567 dGTP binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0106375 deoxynucleoside triphosphate hydrolase activity
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006203 dGTP catabolic process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006955 immune response
GO:0006974 DNA damage response
GO:0009264 deoxyribonucleotide catabolic process
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0045087 innate immune response
GO:0045088 regulation of innate immune response
GO:0046061 dATP catabolic process
GO:0051289 protein homotetramerization
GO:0051607 defense response to virus
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0110025 DNA strand resection involved in replication fork processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005886 plasma membrane
GO:0035861 site of double-strand break
GO:0097197 tetraspanin-enriched microdomain

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tdw, PDBe:8tdw, PDBj:8tdw
PDBsum8tdw
PubMed37930833
UniProtQ9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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