Structure of PDB 8tdh Chain B

Receptor sequence

>8tdhB (length=451) Species: 239759 (Alistipes)

DKLNILGVGIGGRGSSVLRGLESQNIIGLCDVDWKYADHVFKRYPAAKKY
NDYRKMFDEMLKSADAVMVATADHTHAIIAADAMTAGKHVYVEKPLTHTV
YESRLLTKLADKYKVATQMGNQGASDEGVRKVCEWIWNGEIGEVRKVETF
TDRPIWPQGLSRPEDDQRIPKTLNWDAFIGPAPYRPYNAIYTPWNFRGWW
DFGTGALGDMACHILHPVFKGLKLGYPTKVQGSSTLLLNESAPMAQTVKF
VFPARDNMPKVAMPEVEVYWYDGGLKPARPEGLPAGKDLNMAGGGVIFYG
TKDTLICGCYGVNPYLVSGRVPNAPKVLREIKESHQMDWVRACKEDADDR
VPSASDFSEAGPFNEMVVMGVLAVRLQNLNRELLWDGPNMRFTNIPDDAT
ISAVIKDGFHIKDGHPTFDKTWTDPVNAQQFAQELIKHTYRDGWKLPDMP
R

3D structure

• PDB: 8tdh An alternative broad-specificity pathway for glycan breakdown in bacteria.
• Chain: B
• Resolution: 2.95 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GLC	B	R318 P319 E320 Y338	R279 P280 E281 Y299
BS02	GLC	B	A125 G126 K127	A86 G87 K88
BS03	GLC	B	D104 H128	D65 H89
BS04	GLC	B	R192 D248 H252 Y349	R153 D209 H213 Y310
BS05	GLC	B	T462 D463 V465	T423 D424 V426
BS06	GLC	B	D240 N278 R414	D201 N239 R375
BS07	GLC	B	V465 E473	V426 E434
BS08	GLC	B	R184 Y338	R145 Y299
BS09	GLC	B	E320 Y338 G339	E281 Y299 G300
BS10	NAD	B	G48 G50 G51 R52 D70 V71 Y75 A109 T110 D112 T114 H115 E132 K133 F217 W233 F235 R236 H252	G9 G11 G12 R13 D31 V32 Y36 A70 T71 D73 T75 H76 E93 K94 F178 W194 F196 R197 H213

External links

• PDB: RCSB:8tdh, PDBe:8tdh, PDBj:8tdh
• PDBsum: 8tdh
• PubMed: 38898276