Structure of PDB 8tcm Chain B

Receptor sequence
>8tcmB (length=313) Species: 672471 (HIV whole-genome vector AA1305#18) [Search protein sequence]
HGPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKIS
KIGPENPYNTPVFAIKTKWRKLVDFRELNKRTQDFPHPAGLKKKKSVTVL
DVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAI
FQSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRTKISELRQHL
LRWGLTTPDGYELHPDKWTGYDPSDLIAEIQKQGQGQWTYQIYQNLKTGK
YARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWT
EYWQATWIPEWEF
3D structure
PDB8tcm Crystal Structure of modified HIV reverse transcriptase p51 domain (FPC1) with picric acid and xanthene bound
ChainB
Resolution1.82 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TNF B Q23 P55 N57 T131 G141 R143 Q25 P57 N59 T122 G132 R134
BS02 TNF B K22 Q23 P133 N137 T139 G141 K24 Q25 P124 N128 T130 G132
BS03 TNF B K20 K22 K22 K24
BS04 ZQT B G152 K154 P157 M184 D185 W410 G143 K145 P148 M175 D176 W307
BS05 ZQT B H-1 I37 M41 E44 F116 H1 I39 M43 E46 F107
External links
PDB RCSB:8tcm, PDBe:8tcm, PDBj:8tcm
PDBsum8tcm
PubMed
UniProtP04585|POL_HV1H2 Gag-Pol polyprotein (Gene Name=gag-pol)

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