Structure of PDB 8tcf Chain B

Receptor sequence
>8tcfB (length=359) Species: 9606 (Homo sapiens) [Search protein sequence]
VHVIIPTENEINTQVTPGEVSIQLRPGAEANFMLKVHPLKKYPVDLYYLV
DVSASMHNNIEKLNSVGNDLSRKMAFFSRDFRLGFGSYVDKTVSPYISIH
PERIHNQCSDYNLDCMPPHGYIHVLSLTENITEFEKAVHRQKISGNIDTP
EGGFDAMLQAAVCESHIGWRKEAKRLLLVMTDQTSHLALDSKLAGIVCPN
DGNCHLKNNVYVKSTTMEHPSLGQLSEKLIDNNINVIFAVQGKQFHWYKD
LLPLLPGTIAGEIESKAANLNNLVVEAYQKLISEVKVQVENQVQGIYFNI
TAICPDGSRKPGMEGCRNVTSNDEVLFNVTVTMKKCDNYAIIKPIGFNET
AKIHIHRNC
3D structure
PDB8tcf De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8.
ChainB
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D151 N207 D209 P211 E212 D90 N146 D148 P150 E151
BS02 MG B S114 S116 E212 S53 S55 E151
External links
PDB RCSB:8tcf, PDBe:8tcf, PDBj:8tcf
PDBsum8tcf
PubMed37704610
UniProtP26012|ITB8_HUMAN Integrin beta-8 (Gene Name=ITGB8)

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