Structure of PDB 8tbh Chain B

Receptor sequence
>8tbhB (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
SMTEYKLVVVGARGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDDAFYTLVREIRKHKEK
3D structure
PDB8tbh Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy
ChainB
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP B G13 V14 G15 K16 S17 A18 F28 V29 D30 Y32 P34 T35 G60 N116 K117 D119 S145 G14 V15 G16 K17 S18 A19 F29 V30 D31 Y33 P35 T36 G61 N117 K118 D120 S146
BS02 MG B S17 T35 S18 T36
BS03 ZNI B P34 T35 I36 A59 Q61 Y64 M67 P35 T36 I37 A60 Q62 Y65 M68
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8tbh, PDBe:8tbh, PDBj:8tbh
PDBsum8tbh
PubMed38589574
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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