Structure of PDB 8tb6 Chain B

Receptor sequence
>8tb6B (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
SFHRVDQKEITQLSHLGQGTRTNVYEGRLRELRVVLKVLDPSHHDIALAF
YETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGH
VPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFI
KLSDPGVGLGALSREERVERIPWLAPECLPSTAMDKWGFGATLLEICFDG
EAPLRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTIL
RDLT
3D structure
PDB8tb6 Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712.
ChainB
Resolution1.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZOI B L595 Q597 G598 V603 V640 K642 T687 E688 Y689 V690 P694 L741 L16 Q18 G19 V24 V35 K37 T82 E83 Y84 V85 P89 L136
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8tb6, PDBe:8tb6, PDBj:8tb6
PDBsum8tb6
PubMed37823891
UniProtP29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (Gene Name=TYK2)

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