Structure of PDB 8tah Chain B

Receptor sequence
>8tahB (length=357) Species: 9913 (Bos taurus) [Search protein sequence]
GRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPMLEVNYPMENGIVRN
WDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNREKIVEVMFETY
QFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRR
LDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQ
KLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAEL
LFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLK
GDVEKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWMTRQEYQEK
GVRVLEK
3D structure
PDB8tah Mechanism of Synergistic Activation of Arp2/3 Complex by Cortactin and WASP-Family Proteins
ChainB
Resolution2.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP B T15 D161 R214 K217 E218 G306 Y310 T11 D130 R183 K186 E187 G275 Y279
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0051015 actin filament binding
Biological Process
GO:0010592 positive regulation of lamellipodium assembly
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:1905168 positive regulation of double-strand break repair via homologous recombination
GO:2001032 regulation of double-strand break repair via nonhomologous end joining
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0005938 cell cortex
GO:0035861 site of double-strand break
GO:0042995 cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tah, PDBe:8tah, PDBj:8tah
PDBsum8tah
PubMed37898612
UniProtA7MB62|ARP2_BOVIN Actin-related protein 2 (Gene Name=ACTR2)

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