Structure of PDB 8ta2 Chain B

Receptor sequence
>8ta2B (length=466) Species: 9606 (Homo sapiens) [Search protein sequence]
GEDWIFLVLLGLLMALVSWVMDYAIAACLQAQQWMSRGLNTSILLQYLAW
VTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIA
KVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNT
EMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAF
IFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGAL
FVYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFM
AGQLSQKETLVTLFDNRTWVRQSTSQAWNPPRANVFLTLVIFILMKFWMS
ALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGISTYRIVPGGYA
VVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQP
SLYDSIIRIKKLPYLP
3D structure
PDB8ta2 Cryo-EM structures of the human CLC-2 voltage gated chloride channel reveal a closed conformational state and pore block by an N-terminal hairpin peptide
ChainB
Resolution2.74 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GH6 B L116 K204 F306 S392 Q393 K394 M460 L29 K117 F219 S305 Q306 K307 M364
BS02 CL B G203 M460 G116 M364
Gene Ontology
Molecular Function
GO:0005247 voltage-gated chloride channel activity
Biological Process
GO:0006821 chloride transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ta2, PDBe:8ta2, PDBj:8ta2
PDBsum8ta2
PubMed38345841
UniProtP51788|CLCN2_HUMAN Chloride channel protein 2 (Gene Name=CLCN2)

[Back to BioLiP]