Structure of PDB 8t9a Chain B

Receptor sequence
>8t9aB (length=379) Species: 9606 (Homo sapiens) [Search protein sequence]
PPVKRSLVYYLKNREVRLQNETSYSRVLHGYAAQQLPSLLKEREFHLGTL
NKVFASQWLNHRQVVCGTKCNTLFVVDVQTSQITKIPILKDCGIHAIELN
PSRTLLATGGDNPNSLAIYRLPTLDPVCVGDDGHKDWIFSIAWISDTMAV
SGSRDGSMGLWEVTDDVLTKSDARHNVSRVPVYAHITHKALKDINCKVRA
LAFNNKNKELGAVSLDGYFHLWKAENTLSKLLSTKLPYCRENVCLAYGSE
WSVYAVGSQAHVSFLDPRQPSYNVKSVCSRERGSGIRSVSFYEHIITVGT
GQGSLLFYDIRAQRFLEENLKLTTGKGWLNHDETWRNYFSDIFPNAVYTH
CYDSSGTKLFVAGGPLPSGLHGNYAGLWS
3D structure
PDB8t9a CryoEM structure of human DDB1-DCAF12 in complex with MAGEA3
ChainB
Resolution3.17 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B K91 F93 K108 H144 R344 P441 S442 K52 F54 K69 H95 R287 P367 S368
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:1990756 ubiquitin-like ligase-substrate adaptor activity
Biological Process
GO:0010506 regulation of autophagy
GO:0016567 protein ubiquitination
GO:0042110 T cell activation
GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0080008 Cul4-RING E3 ubiquitin ligase complex

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Biological Process
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Cellular Component
External links
PDB RCSB:8t9a, PDBe:8t9a, PDBj:8t9a
PDBsum8t9a
PubMed
UniProtQ5T6F0|DCA12_HUMAN DDB1- and CUL4-associated factor 12 (Gene Name=DCAF12)

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