Structure of PDB 8t7o Chain B

Receptor sequence

>8t7oB (length=392) Species: 9606 (Homo sapiens) [Search protein sequence]

KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDAT
NDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNI
LGGTVFREAIICKNIPRLVSGWVKPIIIGHHQYRATDFVVPGPGKVEITY
TPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWP
LYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVA
QAMKSEGGFIWACKNSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQK
GQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGF
MTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAK

3D structure

PDB

8t7o Mechanistic and Biostructural Studies of Mutant IDH1

Chain

Resolution

2.053 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	IV3	B	L120 W124 I130 M259 W267 C269 N271	L118 W122 I128 M253 W261 C263 N265
BS02	NAP	B	T75 T77 R82 L288 H309 G310 T311 T313 R314 H315 N328 D375	T73 T75 R80 L267 H288 G289 T290 T292 R293 H294 N307 D354

External links

PDB	RCSB:8t7o, PDBe:8t7o, PDBj:8t7o
PDBsum	8t7o
PubMed
UniProt	O75874\|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (Gene Name=IDH1)

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