Structure of PDB 8t7n Chain B

Receptor sequence
>8t7nB (length=393) Species: 9606 (Homo sapiens) [Search protein sequence]
KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDAT
NDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNI
LGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYQYRATDFVVPGPGKVEI
TYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKG
WPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDM
VAQAMKSEGGFIWACKNLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQ
KGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAG
FMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAK
3D structure
PDB8t7n Mechanistic and Biostructural Studies of Mutant IDH1
ChainB
Resolution2.26 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP B A74 T75 T77 R82 H309 G310 T311 V312 T313 R314 H315 N328 D375 A72 T73 T75 R80 H289 G290 T291 V292 T293 R294 H295 N308 D355
BS02 ZT3 B R109 A111 I113 L120 W124 I128 I130 V255 W267 M291 R107 A109 I111 L118 W122 I126 I128 V251 W263 M271
External links
PDB RCSB:8t7n, PDBe:8t7n, PDBj:8t7n
PDBsum8t7n
PubMed
UniProtO75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (Gene Name=IDH1)

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