Structure of PDB 8t7d Chain B

Receptor sequence

>8t7dB (length=390) Species: 9606 (Homo sapiens) [Search protein sequence]

KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDAT
NDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNI
LGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYTDFVVPGPGKVEITYTP
SDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLY
LSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQA
MKSEGGFIWACKNYGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQE
TSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTK
DLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL

3D structure

PDB

8t7d Mechanistic and Biostructural Studies of Mutant IDH1

Chain

Resolution

3.444 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZT3	B	R109 A111 I113 W124 I128 W267 M291	R107 A109 I111 W122 I126 W259 M267

External links

PDB	RCSB:8t7d, PDBe:8t7d, PDBj:8t7d
PDBsum	8t7d
PubMed
UniProt	O75874\|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (Gene Name=IDH1)

[Back to BioLiP]