Structure of PDB 8t55 Chain B

Receptor sequence
>8t55B (length=334) Species: 9606 (Homo sapiens) [Search protein sequence]
QPFIVLGQEEYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQT
KASSISKSPLLSLEWATKRDRLLLLGSGVGTVRLYDTEAKKNLCEININD
NMPRILSLACSPNGASFVCSAAAPSLTSQVPGRLLLWDTKTMKQQLQFSL
DPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVY
SVEFSYDENTVYSIGEDGKFIQWNIHKSGLKVSEYSLPSDATGPFVLSGY
SGYKQVQVPRGRLFAFDSEGNYMLTCSATGGVIYKLGEKVLESCLSLGGH
RAPVVTVDWSTAMDCGTCLTASMDGKIKLTTLLA
3D structure
PDB8t55 Co-crystal structure of the WD-repeat domain of human WDR91 in complex with MR46654
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZI3 B L467 L477 L486 C487 T532 K533 M535 L74 L84 L93 C94 T139 K140 M142
Gene Ontology
Molecular Function
GO:0141039 phosphatidylinositol 3-kinase inhibitor activity
Biological Process
GO:0045022 early endosome to late endosome transport
GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:8t55, PDBe:8t55, PDBj:8t55
PDBsum8t55
PubMed37996079
UniProtA4D1P6|WDR91_HUMAN WD repeat-containing protein 91 (Gene Name=WDR91)

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