Structure of PDB 8t4v Chain B

Receptor sequence
>8t4vB (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
GMTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TSLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDDAFYTLVREIRKHKEK
3D structure
PDB8t4v Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D.
ChainB
Resolution1.47 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP B G13 V14 G15 K16 S17 A18 D30 N116 K117 D119 L120 S145 A146 K147 G14 V15 G16 K17 S18 A19 D31 N117 K118 D120 L121 S146 A147 K148
BS02 Y63 B D12 A59 G60 Q61 E62 Y64 R68 D69 M72 H95 Y96 Q99 D13 A60 G61 Q62 E63 Y65 R69 D70 M73 H96 Y97 Q100
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8t4v, PDBe:8t4v, PDBj:8t4v
PDBsum8t4v
PubMed38443470
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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