Structure of PDB 8szp Chain B

Receptor sequence

>8szpB (length=860) Species: 9606 (Homo sapiens)

TVEPYKVNLSQDLEHQLQNIIQELNLEILPPPEDPSVPVALNIGKPSQRQ
NQVGVVPWSPPQSNWNPWTSSNIDEGPLAFATPEQISMDLKNELMYQLEQ
DHDLQAILQERELLPVKKFESEILEAISQNSVVIIRGATGCGKTTQVPQF
ILDDFIQNDRAAECNIVVTQPRRISAVSVAERVAFERGEEPGKSCGYSVR
FESILPRPHASIMFCTVGVLLRKLEAGIRGISHVIVDEIHERDINTDFLL
VVLRDVVQAYPEVRIVLMSATIDTSMFCEYFFNCPIIEVYGRTYPVQEYF
LEDCIQMTHFVPPPDANCNLICGDEYGPETRLSMSQLNEKETPFELIEAL
LKYIETLNVPGAVLVFLPGWNLIYTMQKHLEMNPHFGSHRYQILPLHSQI
PREEQRKVFDPVPVGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFT
AHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFERLETHMT
PEMFRTPLHEIALSIKLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELD
ALDANDELTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAICTIAAATCFP
EPFINEGKRLGYIHRNFAGNRFSDHVALLSVFQAWDDARMGGEEAEIRFC
EHKRLNMATLRMTWEAKVQLKEILINSGFPEDCLLTQVFTNTGPDNNLDV
VISLLAFGVYPNVCYHKEKRKILTTEGRNALIHKSSVNCPFSSQDMKYPS
PFFVFGEKIRTRAISAKGMTLVTPLQLLLFASKKVQSDGQIVLVDDWIKL
QISHEAAACITGLRAAMEALVVEVTKQPAIISQLDPVNERMLNMIRQISR
PSAAGINLMI

3D structure

• PDB: 8szp Crystal structures of DExH-box RNA helicase DHX9
• Chain: B
• Resolution: 2.62 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	B	T413 G414 G416 K417 T418 T419 R456 F699 T721 N723	T139 G140 G142 K143 T144 T145 R182 F409 T431 N433
BS02	MG	B	T418 E512	T144 E238

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003725 double-stranded RNA binding
• GO:0005524 ATP binding
• GO:0033679 3'-5' DNA/RNA helicase activity

External links

• PDB: RCSB:8szp, PDBe:8szp, PDBj:8szp
• PDBsum: 8szp
• PubMed: 37860960
• UniProt: Q08211|DHX9_HUMAN ATP-dependent RNA helicase A (Gene Name=DHX9)