Structure of PDB 8szi Chain B

Receptor sequence
>8sziB (length=802) Species: 9606 (Homo sapiens) [Search protein sequence]
YGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFR
WLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNK
HIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSF
LRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEER
DICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEI
VRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREF
LKKVHPRKSVHNGFAKEFWEETFNCHLQERPLCTGDENISSVETPYIDYT
HLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLK
HLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYN
VYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCC
FECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPF
GIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCF
SSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKNLQ
FLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALG
FLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPA
YASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRC
ST
3D structure
PDB8szi Allosteric modulation and G-protein selectivity of the Ca2+-sensing receptor
ChainB
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR B F806 F854 F732 F780
BS02 CA B N82 L88 L91 N63 L69 L72
BS03 TRP B T145 A168 Y218 E297 T112 A135 Y185 E264
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8szi, PDBe:8szi, PDBj:8szi
PDBsum8szi
PubMed38326620
UniProtP41180|CASR_HUMAN Extracellular calcium-sensing receptor (Gene Name=CASR)

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