Structure of PDB 8szh Chain B

Receptor sequence

>8szhB (length=812) Species: 9606 (Homo sapiens)

YGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFR
WLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNK
IDSLNLDCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRL
LSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGI
EKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSG
PDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALK
AGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQERPLCTGDENIS
SVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADI
KKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGS
IVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRK
GIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKE
IEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSY
LLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRV
LLVFEAKNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFIT
CHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIF
FIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKP
SRNTIEEVRCST

3D structure

• PDB: 8szh Allosteric modulation and G-protein selectivity of the Ca2+-sensing receptor
• Chain: B
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	YP4	B	Q681 F684 E767 T780 W818 Y825	Q629 F632 E703 T716 W754 Y761
BS02	CA	B	N82 L91	N63 L72
BS03	TRP	B	S147 A168 S170 Y218	S124 A145 S147 Y195

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8szh, PDBe:8szh, PDBj:8szh
• PDBsum: 8szh
• PubMed: 38326620
• UniProt: P41180|CASR_HUMAN Extracellular calcium-sensing receptor (Gene Name=CASR)