Structure of PDB 8szf Chain B

Receptor sequence

>8szfB (length=801) Species: 9606 (Homo sapiens)

YGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFR
WLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNK
IDSLHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQ
FKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREE
AEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPL
IKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPG
FREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGRPLCTGDENISSVETP
YIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEA
WQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKE
VGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEG
EPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLS
WTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFS
LLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRGLNLQF
LLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGF
LIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAY
ASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCS
T

3D structure

• PDB: 8szf Allosteric modulation and G-protein selectivity of the Ca2+-sensing receptor
• Chain: B
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TRP	B	T145 A168 Y218 E297 A298	T116 A139 Y189 E268 A269
BS02	CA	B	N82 S84 L88	N63 S65 L69
BS03	YP4	B	Q681 F684 L770 L773 W818	Q624 F627 L695 L698 W743

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8szf, PDBe:8szf, PDBj:8szf
• PDBsum: 8szf
• PubMed: 38326620
• UniProt: P41180|CASR_HUMAN Extracellular calcium-sensing receptor (Gene Name=CASR)