Structure of PDB 8sze Chain B

Receptor sequence
>8szeB (length=150) Species: 632 (Yersinia pestis) [Search protein sequence]
GMIISLIAALAADRVIHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPG
RLNIVISSQPGTDERVTWAASIEEALAFAGNAEEVMVMGGGRVYKQFLDR
ANRMYLTHIDAEVTHFPDYEPDEWESVFSEFHDADEANSHSYCFEILERR
3D structure
PDB8sze Crystal structure of Yersinia pestis dihydrofolate reductase in complex with Trimethoprim
ChainB
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.5.1.3: dihydrofolate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TOP B I6 A7 H24 D28 L29 F32 M95 I7 A8 H17 D21 L22 F25 M88
Gene Ontology
Molecular Function
GO:0004146 dihydrofolate reductase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0050661 NADP binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0046452 dihydrofolate metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046655 folic acid metabolic process
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8sze, PDBe:8sze, PDBj:8sze
PDBsum8sze
PubMed
UniProtA0A3N4BLI0

[Back to BioLiP]