Structure of PDB 8sx2 Chain B

Receptor sequence
>8sx2B (length=308) Species: 9606 (Homo sapiens) [Search protein sequence]
SEQLQALLLEEVMNSSTLSQEVSDLVEMIWAEALGHLEHMLLKPVNRISL
NDVSKAEGILLLVKAALKNGETAEQLQKMMTEFYRLIPHKGTMPKEVNLG
LLAKKADLCQLIRDMVNVCPPSLAKYRALRCKIEHVEQNTEEFLRVRKEV
LQNHHSKSPVDVLQIFRVGRVNETTEFLSKLGNVRPLLHGSPVQNIVGIL
CRGLLLPKVGNLGSGIYFSDSLSTSIKYSHPGETDGTRLLLICDVALGKC
MDLHEKDFSLTEAPPGYDSVHGVSQTASVTTDFEDDEFVVYKTNQVKMKY
IIKFSMPG
3D structure
PDB8sx2 Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP
ChainB
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UHB B H438 G439 S440 N444 G447 I448 G452 L453 L454 P456 Y477 S485 Y488 H189 G190 S191 N195 G198 I199 G203 L204 L205 P207 Y217 S225 Y228
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:8sx2, PDBe:8sx2, PDBj:8sx2
PDBsum8sx2
PubMed37971310
UniProtQ9UKK3|PARP4_HUMAN Protein mono-ADP-ribosyltransferase PARP4 (Gene Name=PARP4)

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