Structure of PDB 8svx Chain B

Receptor sequence
>8svxB (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVAAKWSQVRKDLCSL
KVSLQLRGEDGSVWNYKPPADSGKEIFSLLPHMADMSTYMFKGIISFAKV
ISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLED
TAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQR
LLRIQDIHPFATPLMQEVFGISLTERHKILHRLLQEGS
3D structure
PDB8svx Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR
ChainB
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WU6 B L209 V211 M243 S247 F281 Q285 F288 W299 Y306 H327 H407 F429 L50 V52 M83 S87 F121 Q125 F128 W139 Y146 H167 H247 F269
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8svx, PDBe:8svx, PDBj:8svx
PDBsum8svx
PubMed38744881
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2);
Q15788

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