Structure of PDB 8svs Chain B

Receptor sequence
>8svsB (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGAKWSQVRKDLCSLKV
SLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVI
SYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEQQ
LLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQE
QFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDI
HPFATPLMQELFGSLTERHKILHRLLQEGS
3D structure
PDB8svs Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR
ChainB
Resolution2.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WU2 B L209 V211 L239 M243 S247 A280 F281 Q285 F288 W299 H327 H407 T408 L411 L428 F429 L48 V50 L78 M82 S86 A119 F120 Q124 F127 W138 H160 H240 T241 L244 L261 F262
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8svs, PDBe:8svs, PDBj:8svs
PDBsum8svs
PubMed38744881
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2);
Q15788

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