Structure of PDB 8svr Chain B

Receptor sequence
>8svrB (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVWSQVRKDLCSLKVS
LQLRGEDGSVWNYKPPADSKEIFSLLPHMADMSTYMFKGIISFAKVISYF
RDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEQQLLL
EPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFA
ITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
ATPLMQELFGISLTERHKILHRLLQEGS
3D structure
PDB8svr Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR
ChainB
Resolution2.92 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WT1 B L209 V211 M243 S247 F281 Q285 F288 W299 H407 L428 F429 L47 V49 M79 S83 F117 Q121 F124 W135 H237 L258 F259
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8svr, PDBe:8svr, PDBj:8svr
PDBsum8svr
PubMed38744881
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2);
Q15788

[Back to BioLiP]