Structure of PDB 8svq Chain B

Receptor sequence
>8svqB (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLEAAKWSQVRKDLC
SLKVSLQLRGEDGSVWNYKPPADSKEIFSLLPHMADMSTYMFKGIISFAK
VISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLE
QQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQL
QEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQ
DIHPFATPLMQELFGISLTERHKILHRLLQEGS
3D structure
PDB8svq Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR
ChainB
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WSX B L209 V211 M243 S247 F281 Q285 F288 W299 Y306 H407 L411 L428 F429 L52 V54 M84 S88 F122 Q126 F129 W140 Y147 H242 L246 L263 F264
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8svq, PDBe:8svq, PDBj:8svq
PDBsum8svq
PubMed38744881
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2);
Q15788

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